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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | CRISPIM, ANDRÉ ALVES | - |
| dc.date.accessioned | 2022-11-07T20:24:28Z | - |
| dc.date.available | 2022-11-07T20:24:28Z | - |
| dc.date.issued | 2022-06-09 | - |
| dc.identifier.uri | https://repositorio.unichristus.edu.br/jspui/handle/123456789/1371 | - |
| dc.description | ALVES, A. M.; DIEL, L. F.; LAMERS, M. L. Macrophages and prognosis of oral squamous cell carcinoma: A systematic review. J Oral Pathol Med. 47, n. 5, p. 460-467, May 2018. ARNETH, B. Tumor microenvironment. Medicina. v. 56, n. 1, p. 15, 2019. CAMPOS, P. S. Modulação do comportamento de células do carcinoma espinocelular oral: influência de fatores químicos e físicos. 2020. DANTAS, T.S. et al. Influence of Educational Level, Stage, and Histological Type on Survival of Oral Cancer in a Brazilian Population: A Retrospective Study of 10 Years Observation. Medicine. v.95, n.3, p. 2314, 2016. tratamento. Brazilian Journal of Otorhinolaryngology, v. 79, n. 2, p. 239-247, 2013. GENTLES, A.J. et al. A human lung tumor microenvironment interactome identifies clinically relevant cell-type cross-talk. Genome biology, v. 21, n. 1, p. 1-22, 2020. GOU, L. et al. Marginal or segmental mandibulectomy: treatment modality selection for oral cancer: a systematic review and meta-analysis. International journal of oral and maxillofacial surgery. v. 47, n. 1, p. 1-10, 2018. GOULART, A.P.S et al. Avaliação da expressão de telomerase (hTert), Ki-67 e P16iNK4a em lesões intraepiteliais cervicais de baixo e alto grau. 2016. INCA. Estimativa de Câncer no Brasil. INCA. 2021. Disponível em: https://www.inca.gov.br/numeros-de-cancer. Acessado em: 25/04/2022. KRISHNAMURTHY, S. et al. Detection of minimal residual disease in blood and bone marrow in early stage breast cancer. Cancer, v. 116, n. 14, p. 3330-3337, 2010. KWON, M. et al. Recurrence and cancer-specific survival according to the expression of IL-4Rα and IL-13Rα1 in patients with oral cavity cancer. European Journal of Cancer, v. 51, n. 2, p. 177-185, 2015. LACET, D. F. R. Qual o significado clínico-patológico da imunoexpressão de CD20 no linfoma de Hodgkin clássico?. 2020. CRAIG, S. G. et al. Recommendations for determining HPV status in patients with oropharyngeal cancers under TNM8 guidelines: a two-tier approach. British Journal of Cancer, v. 120, n. 8, p. 827-833, 2019. DE OLIVEIRA FILHO, O. V. et al. Mismatch Repair Proteins in Oropharyngeal Squamous Cell Carcinoma: A Retrospective Observational Study.Head and Neck Pathology, v. 15, n. 3, p. 803-816, 2021. GALBIATTI, A.L.S. et al. Câncer de cabeça e pescoço: causas, prevenção e 24 LIU, F. et al. TBL1XR1 Is Highly Expressed in Gastric Cancer and Predicts Poor Prognosis. Dis Markers, 2016. LU, X. et al. The impact of tobacco exposure on tumor microenvironment and prognosis in lung adenocarcinoma by integrative analysis of multi-omics data.International Immunopharmacology, v. 101, p. 108253, 2021. LU, Y. et al. Epigenetic silencing of the DNA mismatch repair gene, MLH1, induced by hypoxic stress in a pathway dependent on the histone demethylase, LSD1. Cell Reports. v.8, n.2, p.501-513, 2014. LYDIATT, W.M. Head and Neck Cancers—Major Changes in the American Joint Committee on Cancer Eighth Edition Cancer Staging Manual. A Cancer Journal for Clinicians, v. 67, p. 122-137, 2017. on survival of patients with upfront resection of pancreatic cancer. Cancers, v. 11, n. 1, p. 39, 2019. NGUYEN J. et al. Morphine stimulates cancer progression and mast cell activation and impairs survival in transgenic mice with breast cancer. British journal of Anaesthesia, v.113, n. 1, p. 4-13, 2014. SANTOS, T.H.B.D.P. et al. Clinical findings and risk factors to oral squamous cell carcinoma in young patients: A 12-year retrospective analysis. Medicina oral, patologia oral y cirugia bucal, v. 21, n. 2, p. e151, 2016. SCUTTI, J. A. B. et al. Carcinoma de células escamosas de cabeça e pescoço (HNSCC): desvendando os mistérios do microambiente tumoral. Revista da Associacao Paulista de Cirurgioes Dentistas, v. 70, n. 2, p. 156-163, 2016. WOLF, G.T. et al. Tumor infiltrating lymphocytes (TIL) and prognosis in oral cavity squamous carcinoma: a preliminary study. Oral oncology. v. 51, n. 1, p. 90-95, 2015 WU, T; DAI, Y. Tumor microenvironment and therapeutic response. Cancer letters, v. 387, p. 61-68, 2017. XIAO, L. et al. Multiple myeloma-associated skin light chain amyloidosis: A case of misdiagnosis. Oncology Letters. v. 11, n. 6, p. 3617-3620, 2016. LYDIATT, W.; O’SULLIVAN, B.; PATEL, S. Major Changes in Head and Neck Staging for. Am Soc Clin Oncol Educ B. v.2018, p.505–514, 2018. MEHANNA, H. et al. 911O Performance of dual p16 and HPV testing for determining prognosis in cancer of the oropharynx, the EPIC-OPC Study. Annals of Oncology, v. 31, p. S658-S659, 2020. MIKSCH, R.C. et al. Prognostic impact of tumor-infiltrating lymphocytes and neutrophils 25 YANG, M. et al. GALC Triggers Tumorigenicity of Colorectal Cancer via Senescent Fibroblasts. Frontiers in Oncology. v. 10, p. 380, 2020 | pt_BR |
| dc.description.abstract | O Carcinoma de Células Escamosas (CEC) representa cerca 95% das neoplasias malignas de boca e orofaringe, apresentando alta incidência e elevada mortalidade sendo uma preocupação de saúde pública. Um cofator cada vez mais reconhecido em muitos tipos de cânceres é o estroma adjacente, também chamado de microambiente tumoral (MAT). O papel do microambiente tumoral na carcinogênese é uma área relativamente recente, mas crescente da pesquisa em biologia do câncer. Porém, pouco se sabe sobre todo o seu papel durante a carcinogênese, que tipo de resposta celular as suas células irão desempenhar e que impactos podem ocasionar na sobrevida dos pacientes. Portanto, este estudo propõe através de um estudo retrospectivo, correlacionar imunoexpressão de marcadores com a sobrevida dos pacientes em carcinomas de orofaringe. Para isso, foi realizado um levantamento de pacientes com CEC em orofaringe (CECOF), diagnosticados no Hospital Haroldo Juaçaba, onde serão avaliados os prontuários e serão utilizadas as biópsias excisionais para realização de imuno- histoquímica através de Tissue Microarray (TMA) para receptores dos marcadores CD3, CD8, CD20, CD68 e FoxP3. A imunomarcação será avaliada através do software ImageJ com fotomicrografia e 10 campos no aumento de 400x, de maneira quantitativa (contagem células e não marcadas). Foram correlacionados também dados sóciodemográficos (idade, sexo, histórico de fumo e de câncer na familia, consumo de álcool), além de dados clínico- patológicos (tipo histológico do tumor, localização primária, estadiamento cTNM). Foram obtidos um total de 25 amostras de tecido perilesional (MRC), 29 amostras de TP (Tumor primário) p16-, 21 amostras de tumor p16+, 16 amostras de ML (Metástase Linfonodal) p16- e 9 amostras de ML p16+. O número de células CD20+ foi significantemente maior em região peritumorais/subepiteliais apenas nas metástases linfonodais p16- e p16+ (p=0,013), mas na região intratumorais/intraepiteliais houve aumento na quantidade de células CD20+ em tumores p16+ e nas metástases linfonodais (p<0,001), o histórico de fumo também aumentou o número de todas as células estudadas intra e peritumorais (p<0.05) exceto CD68 (p=0.194 e p=0.501, respectivamente. Na análise de sobrevida, nenhuma característica clínica influenciou significantemente as curvas de sobrevida global, mas os tumores p16+ com mais células CD3+ (p=0.004) e CD68+ (p=0.003) peritumorais e CD8+ intratumorais (p=0.026) apresentaram melhor prognóstico. A tendência no aumento do número de todas as células estudadas intra e peritumorais correlacionando com histórico de fumo pode sugerir um desenvolvimento significativo na piora do quadro clínico destes pacientes. Em conclusão, nossos dados indicam que altas densidades de T CD3 + CD68+ ao redor e CD8 + no centro do tumor e margens invasivas associam-se significativamente à melhora da sobrevida global em pacientes com CECOF primário. | pt_BR |
| dc.language.iso | pt_BR | pt_BR |
| dc.subject | Microambiente Tumoral | pt_BR |
| dc.subject | Sobrevida | pt_BR |
| dc.subject | Carcinoma de Células Escamosas | pt_BR |
| dc.subject | Câncer de Orofaringe. | pt_BR |
| dc.title | INFLUÊNCIA DO MICROAMBIENTE TUMORAL NO PROGNÓSTICO DE PACIENTES COM CARCINOMA DE CÉLULAS ESCAMOSAS DE OROFARINGE | pt_BR |
| dc.type | TCC | pt_BR |
| dc.title.ingles | Influence of the tumor microenvironment on the prognosis of patients with oropharyngeal squamous cell carcinoma | pt_BR |
| dc.description.resumo_abstract | Squamous Cell Carcinoma (SCC) represents about 95% of malignant neoplasms of the mouth and oropharynx, with high incidence and high mortality, being a public health concern. An increasingly recognized cofactor in many types of cancer is the adjacent stroma, also called the tumor microenvironment (MAT). The role of the tumor microenvironment in carcinogenesis is a relatively recent but growing area of research in cancer biology, but little is known about its entire role during carcinogenesis and what type of cellular response its cells will play and what impacts they may have. in patient survival. Therefore, this study proposes, through a retrospective study, to correlate this immunoexpression of markers with the survival of patients with oropharyngeal carcinomas. For this, a survey of a patient with SCC in the oropharynx (CECOF) will be carried out, diagnosed at the Haroldo Juaçaba Hospital, where the medical records will be evaluated and excisional biopsies will be used to perform immunohistochemistry through Tissue Microarray (TMA) for receptors of the markers CD3, CD8, CD20, CD68 and FoxP3. Immunomarking will be evaluated using ImageJ software with photomicrography and 10 fields at 400x magnification, quantitatively (cell count and unlabeled). Sociodemographic data (age, sex, smoking and cancer history in the family, alcohol consumption) were also correlated, as well as clinicopathological data (tumor histological type, primary location, cTNM staging). A total of 25 perilesional tissue samples, 29 p16-TP samples, 21 p16+ tumor samples, 16 p16-ML samples and 9 p16+ ML samples were obtained. The number of CD20+ cells was significantly higher in the peritumoral/subepithelial region only in p16- and p16+ lymph node metastases (p=0.013), but in the intratumoral/intraepithelial region there was an increase in the amount of CD20+ cells in p16+ tumors and in lymph node metastases (p< 0.001), smoking history also increased the number of all intra and peritumoral cells studied (p<0.05) except CD68 (p=0.194 and p=0.501, respectively. In the survival analysis, no clinical feature significantly influenced the survival curves overall, but p16+ tumors with more peritumoral CD3+ (p=0.004) and CD68+ (p=0.003) and intratumoral CD8+ cells (p=0.026) had a better prognosis. smoking history may suggest a significant development in the worsening of the clinical condition of these patients. In conclusion, our data indicate that high densities of CD3 + CD68+ T at and CD8+ in the center of the tumor and invasive margins are significantly associated with improved overall survival in patients with primary CECOF. | pt_BR |
| Appears in Collections: | Odontologia - Trabalhos de Conclusão de Curso - Campus BENFICA | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| CRISPIM, ANDRÉ.pdf | 1.62 MB | Adobe PDF |  View/Open |
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