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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | Dantas, Thinali Sousa | - |
| dc.contributor.author | VASCONCELOS, Monalise Cunha | - |
| dc.date.accessioned | 2022-03-18T12:09:15Z | - |
| dc.date.available | 2022-03-18T12:09:15Z | - |
| dc.date.issued | 2021-12-10 | - |
| dc.identifier.uri | https://repositorio.unichristus.edu.br/jspui/handle/123456789/1305 | - |
| dc.description | 1. Hu Z, Yang R, Li L, Mao L, Liu S, QiaoS, Ren G, Hu J. Validation of Gene Profiles forAnalysis of Regional Lymphatic Metastases in Head and Neck Squamous Cell Carcinoma.Front Mol Biosci. 2020;4;7:3. 2. Melo LC, Silva MC, Bernardo JMP, Marques EB, Leite ICG.Epidemiological profile ofincident cases of oral and pharyngeal cancer. RGO. 2010;58(3):351-5. 3.Brener S,Jeunon FA,Barbosa AA,Grandinetti HAM.Oral squamous cell carcinoma: aliterature review of patient profile, clinicalstaging and proposed treatment.Rev Bras Cancerol2007;53(1):63-69 4.Dantas TS, de Barros Silva PG, Sousa EF, da Cunha Mdo P, de Aguiar AS, Costa FW, MotaMR, Alves AP, Sousa FB.Influence of Educational Level, Stage, and Histological Type onSurvival of Oral Cancer in a Brazilian Population: A Retrospective Study of 10 YearsObservation.Medicine (Baltimore). 2016;95(3):e2314. 5. Bittar RF, Ferraro HP, Ribas MH, Lehn CN.Predictive factors of occult neck metastasis inpatients with oral squamous cell carcinoma. Braz J Otorhinolaryngol. 2016;82(5):543-7. 6. Bobdey S, Sathwara J, Jain A, Saoba S, Balasubramaniam G. Squamous cell carcinoma ofbuccal mucosa: An analysis of prognostic factors.South Asian J Cancer. 2018;7(1):49-54. 7.Colares N, Souza Rodrigues DF, Freitas MO, Dantas TS, Cunha MDPSS, Sousa FB, BarrosSilva PG.Smoking History Decreases Survival in Patients with Squamous Cell Carcinoma ofthe Mouth: A Retrospective Study with 15 Years of Follow-up.Asian Pac J Cancer Prev.2019;20(6):1781-7. 8.Silva PGB, Soares IL, Mendes FHO, Campêlo CSP, Cunha MPSS, Mota MRL, Dantas TS,Sousa FB.Alcohol Consumption History as a Predictive Factor of Survival in Patients withMouth and Oropharyngeal Squamous Cell Carcinoma: Follow-up of15 Years.Rev BrasCancerol, 2019;66(1):e-02573. 9.Barros-Silva PG, Fontes-Borges MM, Costa-Dias C, Mota-Lemos JV, SocorroSaldanha-Cunha MD, Fernandes-Souza E, Sousa-Dantas T, Bitu-Sousa F..Clinical- pathological andsociodemographic factors associatedwith the distant metastasis and overall survival of oralcavity and oropharynx squamous cell carcinoma.Med Oral Patol Oral Cir Bucal.2020;25(3):e375-e382. 10.Aquino RCA, Lima MLLT, Menezes CRCX, Rodrigues M.Epidemiologic aspects ofmortality from oralcancer: understandingthe risks to enable the early detection of changes incommunication.Rev CEFAC.2015;17(4):1254-61. 11. Roh JL,Park JP, Kim JS, Lee JH, Cho KJ, Choi SH, Nam SY, Kim SY. 18FFluorodeoxyglucose PET/CT in head and neck squamous cell carcinoma with negative neckpalpation findings: a prospective study.Radiology. 2014;271(1):153-61 12.Durazzo MD, Tavares MR, Araujo CEN, Brandão Neto JS, Matsunaga P, Potenza AS, etal. Perfil dosportadores de câncer da cavidade oral operados de 1994 a 1998: predomínio dedoença local avançada e aumento da incidência de mulheres. Rev Bras Cir Cab Pesc. 2001;25:7-10 13.MontoroJRMC,HiczHA,Souza L, Livingstone D, Melo DH, Tiveron RC,MamedeRCM.Prognostic factors in squamous cell carcinoma of the oral cavity. Braz J Otorhinolaryngol.2008;74(6):861-6. 14. Klingelhöffer C1, Gründlinger A2, Spanier G2, Schreml S3, Gottsauner M2, Mueller S2,Meier JK2, Reichert TE2, Ettl T2. Patients with unilateral squamous cell carcinoma of thetongue and ipsilateral lymph node metastasis do not profit from bilateral neck dissection. 15. De Silva RK, Siriwardena BSMS, Samaranayaka A, Abeyasinghe WAMUL, TilakaratneWM A model to predict nodal metastasis in patients with oral squamous cell carcinoma.PLoSOne.2018;13(8):e0201755. 16. Aires FT, Lin CS, Matos LL, Kulcsar MAV, Cernea CR. Risk Factors for Distant Metastasis in Patients with Oral Cavity Squamous Cell Carcinoma Undergoing Surgical Treatment. ORL J Otorhinolaryngol Relat Spec. 2017;79(6):347-55. 17. Soni S, Soni TP, Patni N. Association Between Nodal Metastasis and Histopathological Factors in Postoperative Gingivo-Buccal Complex Squamous Cell Carcinoma: A Retrospective Study. Gulf J Oncolog. 2019;1(29):66-71. 18. Zhan KY, Morgan PF, Neskey DM, Kim JJ, Huang AT, Garrett-Mayer E, Day TA. Preoperative Predictors of Occult Nodal Disease in cT1N0 Oral Cavity Squamous Cell Carcinoma: Review of 2623 Cases. Head Neck. 2018;40(9):1967-76. 19. Hamada M, Ebihara Y, Nagata K, Yano M, Kogashiwa Y, Nakahira M, Sugasawa M, Nagatsuka H, Yasuda M. Podoplanin is an efficient predictor of neck lymph node metastasis in tongue squamous cell carcinoma with low tumor budding grade. Oncol Lett. 2020;19(4):2602-8. 20. Ebihara Y, Yoshida S, Nakahira M, Kogashiwa Y, Enoki Y, Kuba K, Inoue H, Minami K, Yasuda M, Sugasawa M. Importance of tumor budding grade as independent prognostic factor for early tongue squamous cell carcinoma. Head Neck. 2019;41(6):1809-15. 21. Li Y, Liu K, Ke Y, Zeng Y, Chen M, Li W, Liu W, Hua X, Li Z, Zhong Y, Xie C, Yu H. Risk Factors Analysis of Pathologically Confirmed Cervical Lymph Nodes Metastasis in Oral Squamous Cell Carcinoma Patients with Clinically Negative Cervical Lymph Node: Results from a Cancer Center of Central China. J Cancer. 2019;10(13):3062-9. 22. Ozturk K, Gode S, Erdogan U, Akyildiz S, Apaydin F. Squamous cell carcinoma of the lip: survival analysis with long-term follow-up. Eur Arch Otorhinolaryngol. 2015;272(11):3545-50. 23. Madani AH, Dikshit M, Bhaduri D, Jahromi AS, Aghamolaei T. Relationship between Selected Socio-Demographic Factors and Cancer of Oral Cavity - A Case Control Study. Cancer Inform. 2010;9:163-8. 24. Polednak AP. Declining Proportion of Incident Squamous Cell Carcinomas of the Oral Cavity Coded as Unknown for American Joint Committee TNM Stage: SEER Registries, 2004-2014. J Registry Manag. 2018;45(3):104-8. 25. DeConde A, Miller ME, Palla B, Lai C, Elashoff D, Chhetri D, St John MA. Squamous cell carcinoma of buccal mucosa: a 40-year review. Am J Otolaryngol. 2012;33(6):673-7. 26. Almeida FCS, Cazal C, Nunes FD, Araújo ME, Dias RB, Silva DP. Prognostic Factors in Oral Cancer. Rev Bras Cienc Saúde. 2011;15(4):471-8. 27. Nagatsuka H, Hibi K, Gunduz M, Tsujigiwa H, Tamamura R, Sugahara T, Sasaki A, Nagai N. Various immunostaining patterns of CD31, CD34 and endoglin and their relationship with lymph node metastasis in oral squamous cell carcinomas. J Oral Pathol Med 2005;34(2):70-6. 28. Comt F, Barge ML, Chevalier J, ROssi M, Zanca M, Alovisetti C, Garrel R, Guerrier B, Costes V. Contribution of the sentinel lymph node detection in oral cavity and oropharynx cancer. Med Nuc. 2004;28(6):108-15. 29. Kaur G, Carnelio S, Rao N, Rao L. Expression of E-cadherin in primary oral squamous cell carcinoma and metastatic lymph nodes: An immunohistochemical study. Indian J Dent Res 2009;20(1):71-6. 30. Alam K, Khan A, Siddiqui F, Jain A, Haider N, Maheswari V. Fine needle aspiration cytology (FNAC), a handy tool for metastatic lymphadenopathy. Internet J Pathology 2010;10(2):25-32. | pt_BR |
| dc.description.abstract | O Carcinoma de Células Escamosas (CCE) apresenta crescimento rápido e alta tendência à metástase para linfonodos cervicais. O objetivo deste estudo é analisar os fatores de risco para metástases nodais em pacientes com CCE e sua influência na sobrevida global. Prontuários médicos de 350 pacientes com CEC foram revisados retrospectivamente e as seguintes informações coletadas: sexo, idade, raça, nível educacional, estado civil, história familiar de câncer, história de tabagismo, consumo de álcool, local do tumor, estadiamento clínico, tratamento e sobrevida global. Os dados foram analisados pelos testes qui-quadrado, exato de Fisher e Log-Rank Mantel Cox (análise bivariada) e regressão logística multinominal e Cox (análise multivariada) (SPSS, p <0,05). Dos 350 prontuários avaliados, 251 apresentam N0, 75 N1, 16 N2 e 8 N3. Sexo masculino (p = 0,013), encaminhamentos de empresas privadas de saúde (p = 0,006), estágio T3 / 4 (p <0,001) e tratamentos não cirúrgicos (p <0,001) estiveram diretamente associados à metástase nodal. Na análise multivariada, homens (p = 0,034) e tumores T3 / 4 (p = 0,002) mostraram-se como fatores independentes de risco para N +. A sobrevida global mediana foi de 43 meses (IC95% = 28,90-57,10). Variáveis como sexo masculino (p = 0,017), idade> 65 anos (p = 0,013), raça parda (p = 0,041), sem história familiar de câncer (p = 0,045), tumores T4 (p = 0,017), N + (p = 0,001) e o tratamento não cirúrgico (p <0,001) diminuíram uma sobrevida global. Os fatores de risco independentes para sobrevida foram sexo masculino (p = 0,041), envolvimento nodal (p = 0,017) e tratamento não cirúrgico (p = 0,030). O gênero masculino e o estádio T são fatores de risco considerados para metástases em linfonodos cervicais em pacientes com CCE. Além disso, a presença de linfonodos com metástases e idade > 65 anos são fatores associados à baixa sobrevida global desses pacientes. | pt_BR |
| dc.language.iso | pt_BR | pt_BR |
| dc.subject | Neoplasias bucais | pt_BR |
| dc.subject | Linfonodos | pt_BR |
| dc.subject | Carcinoma de células escamosas | pt_BR |
| dc.subject | Análise de sobrevida | pt_BR |
| dc.title | Metástase nodal no carcinoma de células escamosas oral: uma análise retrospectiva dos fatores de risco e influência na sobrevida global | pt_BR |
| dc.type | TCC | pt_BR |
| dc.title.ingles | Nodal metastasis in oral squamous cell carcinoma: a retrospective analysis of risk factors and influence on overall survival | pt_BR |
| dc.description.resumo_abstract | Background: Oral squamous cell carcinoma (OSCC) presents rapid growth and high tendency toward metastasis to cervical lymph nodes. Considering that nodal involvement is a prognostic predictor in patients with head and neck tumors, our aim is to analyze risk factors for nodal metastasis in patients with OSCC and its influence on overall survival. Methods: Medical records of 350 patients with OSCC were retrospectively reviewed and the following information was collected: gender, age, race, educational level, marital status, family history of cancer, smoking history, alcohol consumption, referrals, tumor site, clinical staging, treatment and overall survival. The data were analyzed using the chi-square, Fisher's exact and Log-Rank Mantel Cox tests (bivariate analysis) and multinomial and Cox logistic regression (multivariate analysis) (SPSS, p <0.05). Results: Of the 350 medical records evaluated, 251 reported N0, 75 N1, 16 N2 and 8 N3. Male gender (p = 0.013), referrals from private health care providers (p = 0.006), T3 / 4 (p <0.001) stage and non-surgical treatments (p <0.001) were directly associated with nodal metastasis. In multivariate analysis, men (p = 0.034) and T3 / 4 tumors (p = 0.002) were shown to be independent risk factors for N +. The median overall survival was 43 months (CI95% = 28.90-57.10). Variables such as male gender (p = 0.017), age >65 years (p = 0.013), mixed race (p = 0.041), no family history of cancer (p = 0.045), T4 tumors (p = 0.017), N + (p = 0.001) and non-surgical treatment (p <0.001) decreased overall survival. The independent risk factors for survival were male gender (p = 0.041), nodal involvement (p = 0.017) and non-surgical treatment (p = 0.030). Conclusion: Male gender and T-stage are significant risk factors for cervical lymph node metastases in patients with OSCC. Moreover, the presence of lymph nodes with metastasis and age >65 years are factors associated with poor overall survival for these patients. | pt_BR |
| Appears in Collections: | Odontologia - Trabalhos de Conclusão de Curso - Campus BENFICA | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| MONALISE CUNHA VASCONCELOS.pdf | 590.43 kB | Adobe PDF |  View/Open |
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