Please use this identifier to cite or link to this item: https://repositorio.unichristus.edu.br/jspui/handle/123456789/1305
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dc.contributor.advisorDantas, Thinali Sousa-
dc.contributor.authorVASCONCELOS, Monalise Cunha-
dc.date.accessioned2022-03-18T12:09:15Z-
dc.date.available2022-03-18T12:09:15Z-
dc.date.issued2021-12-10-
dc.identifier.urihttps://repositorio.unichristus.edu.br/jspui/handle/123456789/1305-
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dc.description.abstractO Carcinoma de Células Escamosas (CCE) apresenta crescimento rápido e alta tendência à metástase para linfonodos cervicais. O objetivo deste estudo é analisar os fatores de risco para metástases nodais em pacientes com CCE e sua influência na sobrevida global. Prontuários médicos de 350 pacientes com CEC foram revisados retrospectivamente e as seguintes informações coletadas: sexo, idade, raça, nível educacional, estado civil, história familiar de câncer, história de tabagismo, consumo de álcool, local do tumor, estadiamento clínico, tratamento e sobrevida global. Os dados foram analisados pelos testes qui-quadrado, exato de Fisher e Log-Rank Mantel Cox (análise bivariada) e regressão logística multinominal e Cox (análise multivariada) (SPSS, p <0,05). Dos 350 prontuários avaliados, 251 apresentam N0, 75 N1, 16 N2 e 8 N3. Sexo masculino (p = 0,013), encaminhamentos de empresas privadas de saúde (p = 0,006), estágio T3 / 4 (p <0,001) e tratamentos não cirúrgicos (p <0,001) estiveram diretamente associados à metástase nodal. Na análise multivariada, homens (p = 0,034) e tumores T3 / 4 (p = 0,002) mostraram-se como fatores independentes de risco para N +. A sobrevida global mediana foi de 43 meses (IC95% = 28,90-57,10). Variáveis como sexo masculino (p = 0,017), idade> 65 anos (p = 0,013), raça parda (p = 0,041), sem história familiar de câncer (p = 0,045), tumores T4 (p = 0,017), N + (p = 0,001) e o tratamento não cirúrgico (p <0,001) diminuíram uma sobrevida global. Os fatores de risco independentes para sobrevida foram sexo masculino (p = 0,041), envolvimento nodal (p = 0,017) e tratamento não cirúrgico (p = 0,030). O gênero masculino e o estádio T são fatores de risco considerados para metástases em linfonodos cervicais em pacientes com CCE. Além disso, a presença de linfonodos com metástases e idade > 65 anos são fatores associados à baixa sobrevida global desses pacientes.pt_BR
dc.language.isopt_BRpt_BR
dc.subjectNeoplasias bucaispt_BR
dc.subjectLinfonodospt_BR
dc.subjectCarcinoma de células escamosaspt_BR
dc.subjectAnálise de sobrevidapt_BR
dc.titleMetástase nodal no carcinoma de células escamosas oral: uma análise retrospectiva dos fatores de risco e influência na sobrevida globalpt_BR
dc.typeTCCpt_BR
dc.title.inglesNodal metastasis in oral squamous cell carcinoma: a retrospective analysis of risk factors and influence on overall survivalpt_BR
dc.description.resumo_abstractBackground: Oral squamous cell carcinoma (OSCC) presents rapid growth and high tendency toward metastasis to cervical lymph nodes. Considering that nodal involvement is a prognostic predictor in patients with head and neck tumors, our aim is to analyze risk factors for nodal metastasis in patients with OSCC and its influence on overall survival. Methods: Medical records of 350 patients with OSCC were retrospectively reviewed and the following information was collected: gender, age, race, educational level, marital status, family history of cancer, smoking history, alcohol consumption, referrals, tumor site, clinical staging, treatment and overall survival. The data were analyzed using the chi-square, Fisher's exact and Log-Rank Mantel Cox tests (bivariate analysis) and multinomial and Cox logistic regression (multivariate analysis) (SPSS, p <0.05). Results: Of the 350 medical records evaluated, 251 reported N0, 75 N1, 16 N2 and 8 N3. Male gender (p = 0.013), referrals from private health care providers (p = 0.006), T3 / 4 (p <0.001) stage and non-surgical treatments (p <0.001) were directly associated with nodal metastasis. In multivariate analysis, men (p = 0.034) and T3 / 4 tumors (p = 0.002) were shown to be independent risk factors for N +. The median overall survival was 43 months (CI95% = 28.90-57.10). Variables such as male gender (p = 0.017), age >65 years (p = 0.013), mixed race (p = 0.041), no family history of cancer (p = 0.045), T4 tumors (p = 0.017), N + (p = 0.001) and non-surgical treatment (p <0.001) decreased overall survival. The independent risk factors for survival were male gender (p = 0.041), nodal involvement (p = 0.017) and non-surgical treatment (p = 0.030). Conclusion: Male gender and T-stage are significant risk factors for cervical lymph node metastases in patients with OSCC. Moreover, the presence of lymph nodes with metastasis and age >65 years are factors associated with poor overall survival for these patients.pt_BR
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