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https://repositorio.unichristus.edu.br/jspui/handle/123456789/1305| Título : | Metástase nodal no carcinoma de células escamosas oral: uma análise retrospectiva dos fatores de risco e influência na sobrevida global |
| Autor : | VASCONCELOS, Monalise Cunha |
| metadata.dc.contributor.advisor: | Dantas, Thinali Sousa |
| Fecha de publicación : | 2021-12-10 |
| Resumen : | O Carcinoma de Células Escamosas (CCE) apresenta crescimento rápido e alta tendência à metástase para linfonodos cervicais. O objetivo deste estudo é analisar os fatores de risco para metástases nodais em pacientes com CCE e sua influência na sobrevida global. Prontuários médicos de 350 pacientes com CEC foram revisados retrospectivamente e as seguintes informações coletadas: sexo, idade, raça, nível educacional, estado civil, história familiar de câncer, história de tabagismo, consumo de álcool, local do tumor, estadiamento clínico, tratamento e sobrevida global. Os dados foram analisados pelos testes qui-quadrado, exato de Fisher e Log-Rank Mantel Cox (análise bivariada) e regressão logística multinominal e Cox (análise multivariada) (SPSS, p <0,05). Dos 350 prontuários avaliados, 251 apresentam N0, 75 N1, 16 N2 e 8 N3. Sexo masculino (p = 0,013), encaminhamentos de empresas privadas de saúde (p = 0,006), estágio T3 / 4 (p <0,001) e tratamentos não cirúrgicos (p <0,001) estiveram diretamente associados à metástase nodal. Na análise multivariada, homens (p = 0,034) e tumores T3 / 4 (p = 0,002) mostraram-se como fatores independentes de risco para N +. A sobrevida global mediana foi de 43 meses (IC95% = 28,90-57,10). Variáveis como sexo masculino (p = 0,017), idade> 65 anos (p = 0,013), raça parda (p = 0,041), sem história familiar de câncer (p = 0,045), tumores T4 (p = 0,017), N + (p = 0,001) e o tratamento não cirúrgico (p <0,001) diminuíram uma sobrevida global. Os fatores de risco independentes para sobrevida foram sexo masculino (p = 0,041), envolvimento nodal (p = 0,017) e tratamento não cirúrgico (p = 0,030). O gênero masculino e o estádio T são fatores de risco considerados para metástases em linfonodos cervicais em pacientes com CCE. Além disso, a presença de linfonodos com metástases e idade > 65 anos são fatores associados à baixa sobrevida global desses pacientes. |
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| Palabras clave : | Neoplasias bucais Linfonodos Carcinoma de células escamosas Análise de sobrevida |
| URI : | https://repositorio.unichristus.edu.br/jspui/handle/123456789/1305 |
| Aparece en las colecciones: | Odontologia - Trabalhos de Conclusão de Curso - Campus BENFICA |
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