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DC Field | Value | Language |
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dc.contributor.advisor | Silva, Paulo Goberlânio Barros | - |
dc.contributor.author | Araújo, Clarice Lioba de | - |
dc.date.accessioned | 2024-08-19T18:53:13Z | - |
dc.date.available | 2024-08-19T18:53:13Z | - |
dc.date.issued | 2024-06-20 | - |
dc.identifier.uri | https://repositorio.unichristus.edu.br/jspui/handle/123456789/1725 | - |
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dc.description.abstract | Tem sido sugerido que o Ellansé, composto por microesferas de policaprolactona (PCL) em solução aquosa de gel de carboximetilcelulose (CMC), seja diluído como forma de aumentar seu rendimento e que o Sculptra®, um polímero sintético apresentado na forma de um pó liofilizado que após reconstituição gera uma matriz que estimula a colagênese, seja reconstituído em períodos menor que o indicado pelo fabricante. Dessa forma, o objetivo do presente trabalho é avaliar o percentual de indução de neocolagênese dos preenchedores Ellansè® e Sculptra® em diferentes formas de apresentação e reconstituição. Para isso, foram utilizado 270 camundongos da linhagem Swiss (Mus musculus) machos entre quatro e seis semanas em cujos subcutâneo do dorso foram aplicados 0,1 ml de solução salina contendo 5% de anestésico local subcutânea; 0,1 ml de Ellansé® sem nenhuma diluição ou diluído 1:1 (50%),1:2 (66%) e 1:4 (83%) ou Sculptra® reconstituído imediatamente antes da aplicação, 2h , 24h ou 72h antes da administração e foram eutanasiados após 15, 30 e 60 dias da administração do material em número de 10/grupo/dia. Foram removidos seus dorsos para análise histológica da quantidade de colágeno utilizando a coloração de Picrosirius Red e imunoexpressão para alfaactina de músculo liso. Teste ANOVA/Bonferroni foi utilizado (p<0,05, GraphPad Prism 5.0). Após 15 dias de administração não houve diferença significativa entre os grupos estudados (p=0,955). Após 30 dias da administração do Ellansé® 83% e 100% (p<0,001) e o grupo Sculptra 72h (p=0,016) apresentaram maior formação de colágeno que o grupo salina. Após 60 dias os grupos com Ellansé® 83% e 100% também apresentaram maior formação de colágeno que o grupo salina (p=0,012) bem como os grupos Sculptra 24h, 48h e 72h (p=0,025). Após 30 dias da administração os grupos Sculptra 24h e 72h apresentam maior imunoexpressão para α-AML (p=0,001), bem como após 60 dias da administração Ellansé® 100% (p=0,012) e Sculptra 24h e 72h (p<0,001). Dessa forma, a mistura da solução de lidocaína com o material de preenchimento inibe a necessidade de bloqueios nervosos ou infiltração local, diminuindo assim a dor relacionada ao tratamento e evitando a distorção tecidual que pode ser provocada pela injeção de anestésicos locais. Ademais, pode ter um impacto positivo no tratamento, melhorando a qualidade do atendimento e a satisfação do paciente. Dessa forma, com a finalidade de neocolagêse a diluição de Ellansé® ou reconstituição de Sculptra® em períodos inferiores às 24h são contraindicados. | pt_BR |
dc.language.iso | pt_BR | pt_BR |
dc.subject | dermal fillers | pt_BR |
dc.subject | colágeno | pt_BR |
dc.subject | policaprolactona | pt_BR |
dc.subject | ácido poli-l-láctico | pt_BR |
dc.title | POLICAPROLACTONA E ÁCIDO POLI-L-LÁTICO: É POSSÍVEL OTIMIZAR E REDUZIR CUSTOS DURANTE HARMONIZAÇÃO OROFACIAL COM INDUTORES DE COLÁGENO? UM ESTUDO IN VIVO | pt_BR |
dc.type | TCC | pt_BR |
dc.title.ingles | POLYCAPROLACTONE AND POLY-L-LACTIC ACID: IS IT POSSIBLE TO OPTIMIZE AND REDUCE COSTS DURING OROFACIAL HARMONIZATION WITH COLLAGEN INDUCERS? AN IN VIVO STUDY | pt_BR |
dc.description.resumo_abstract | It has been suggested that Ellansé®, composed of polycaprolactone (PCL) microspheres in an aqueous solution of carboxymethyl cellulose (CMC) gel, be diluted as a way of increasing its yield and that Sculptra®, a synthetic polymer presented in the form of a powder freeze-dried product that, after reconstitution, generates a matrix that stimulates collagengenesis, must be reconstituted in periods shorter than that indicated by the manufacturer. Therefore, the objective of the present work is to evaluate the percentage of neocollagenesis induction of Ellansé® and Sculptra® fillers in different forms of presentation and reconstitution. For this, 270 male Swiss mice (Mus musculus) aged between four and six weeks were used, to which 0.1 ml of saline solution containing 5% local anesthetic was applied subcutaneously; 0.1 ml of Ellansé® without any dilution or diluted 1:1 (50%), 1:2 (66%) and 1:4 (83%) or Sculptra® reconstituted immediately before application, 2h, 24h or 72h before administration and were euthanized after 15, 30 and 60 days of administration of the material in a number of 10/group/day. Their backs were removed for histological analysis of the amount of collagen using Picrosirius Red staining and immunoexpression for alpha-smooth muscle actin. ANOVA/Bonferroni test was used (p<0.05, GraphPad Prism 5.0). After 15 days of administration there was no significant difference between the groups studied (p=0.955). After 30 days of administration of Ellansé®, 83% and 100% (p<0.001) and the Sculptra 72h group (p=0.016) showed greater collagen formation than the saline group. After 60 days, the groups with Ellansé® 83% and 100% also showed greater collagen formation than the saline group (p=0.012) as well as the Sculptra 24h, 48h and 72h groups (p=0.025). After 30 days of administration, the Sculptra 24h and 72h groups showed higher immunoexpression for α-AML (p=0.001), as well as after 60 days of administration Ellansé® 100% (p=0.012) and Sculptra 24h and 72h (p<0.001). In this way, mixing the lidocaine solution with the filling material inhibits the need for nerve blocks or local infiltration, thus reducing treatment-related pain and avoiding tissue distortion that can be caused by the injection of local anesthetics. Furthermore, it can have a positive impact on treatment, improving the quality of care and patient satisfaction. Therefore, for the purpose of neocolagesis, dilution of Ellansé® or reconstitution of Sculptra® in periods of less than 24 hours are contraindicated. | pt_BR |
Appears in Collections: | Odontologia - Trabalhos de Conclusão de Curso - Campus PARQUE ECOLÓGICO |
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