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https://repositorio.unichristus.edu.br/jspui/handle/123456789/2102Registro completo de metadados
| Campo DC | Valor | Idioma |
|---|---|---|
| dc.contributor.advisor | Silva, Paulo Goberlânio de Barros | - |
| dc.contributor.author | Aguiar, Gladyson Lucas Rodrigues | - |
| dc.date.accessioned | 2026-06-15T11:44:24Z | - |
| dc.date.available | 2026-06-15T11:44:24Z | - |
| dc.date.issued | 2026-06-06 | - |
| dc.identifier.uri | https://repositorio.unichristus.edu.br/jspui/handle/123456789/2102 | - |
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| dc.description.abstract | Os cânceres de boca e de orofaringe representam a predominante maioria dos tumores malignos de cabeça e pescoço e tendo em vista que vias inflamatórias podem exercer importante papel no seu prognóstico, Avaliar a associação entre a imunoexpressão de proteínas do complexo Mismatch Repair nos Fatores de Transcrição NFkB nos cânceres de boca (CEC-b) e de orofaringe (CRC-o) .Foram selecionados 76 CEC-b e 52 CRC-o peças cirúrgicas cujos dados sociodemográficos como idade, sexo, grau de instrução, estado civil, profissão, raça/cor, tipo de entrada no hospital, religião, consumo de álcool e fumo foram levantados. As amostras foram submetidas a imuno-histoquímica para NF-kB p65 MSH2, MSH6, PMS2 e MLH1 em seguida contagem de células imunopositivas em núcleo e/ou citoplasma. Testes qui-quadrado, Log-Rank Mantel-Cox e regressão de Cox foram usados (p<0,05). Os tumores pT3-pT4 apresentaram perda de expressão de MLH1 (p=0,031) comparado com os tumores pT1-pT2 e os tumores com metástase nodal apresentaram perda de expressão de p53 (p=0,010) (Tabela 2) .Nos tumores de orofaringe p16+ os pacientes com idade <60 anos (82.77±21.11%) apresentaram perda de expressão de MLH1 que os pacientes com idade superior a 60 anos (82.77±21.11%, p=0,042) e os pacientes com tumores pT3-pT4 (21.89±31.74%) apresentaram menor expressão de MSH6 que os pacientes com tumores pT1-pT2 (67.09±21.30, p=0,002) (Material Suplementar 2). A perda de expressão de MMR está associada com progressão tumoral e prognóstico em tumores de cabeça e pescoço e p53, p16 e NFkB parecem ser intermediários importantes. | pt_BR |
| dc.subject | neoplasmas de orofaringe | pt_BR |
| dc.subject | neoplasmas de boca | pt_BR |
| dc.subject | DNA Mismatch Repair | pt_BR |
| dc.subject | proteínas Muts | pt_BR |
| dc.title | INFLUÊNCIA DA IMUNOEXPRESSÃO DAS PROTEÍNAS DO COMPLEXO MISMATCH REPAIR NO FATOR DE TRANSCRIÇÃO NUCLEAR KAPPA (NFkB) B NOS CÂNCERES DE BOCA E DE OROFARINGE | pt_BR |
| dc.type | TCC | pt_BR |
| dc.title.ingles | Influence of the immunoexpression of Mismatch Repair complex proteins on nuclear factor kappa (NFkB) B transcription factor in oral and oropharyngeal cancers | pt_BR |
| dc.description.resumo_abstract | Oral and oropharyngeal cancers represent the predominant majority of malignant head and neck tumors, and considering that inflammatory pathways can play an important role in their prognosis, this study aimed to evaluate the association between the immunoexpression of Mismatch Repair complex proteins in NF-κB transcription factors in oral (b-squamous cell carcinoma - SCC) and oropharyngeal (o-squamous cell carcinoma - O-squamous cell carcinoma) cancers. Seventy-six b-squamous cell carcinomas and fifty-two o-squamous cell carcinomas were selected, and sociodemographic data such as age, sex, education level, marital status, profession, race/color, type of hospital admission, religion, alcohol consumption, and smoking habits were collected. The samples were subjected to immunohistochemistry for NF-κB p65 MSH2, MSH6, PMS2, and MLH1, followed by counting of immunopositive cells in the nucleus and/or cytoplasm. Chi-square, Log-Rank Mantel-Cox, and Cox regression tests were used (p<0.05). pT3-pT4 tumors showed loss of MLH1 expression (p=0.031) compared to pT1-pT2 tumors, and tumors with nodal metastasis showed loss of p53 expression (p=0.010) (Table 2). In p16+ oropharyngeal tumors, patients under 60 years of age (82.77±21.11%) showed less loss of MLH1 expression than patients over 60 years of age (82.77±21.11%, p=0.042), and patients with pT3-pT4 tumors (21.89±31.74%) showed lower MSH6 expression than patients with pT1-pT2 tumors (67.09±21.30, p=0.002) (Supplementary Material 2). Loss of MMR expression is associated with tumor progression and prognosis in head and neck tumors, and p53, p16, and NFkB appear to be important intermediaries. | pt_BR |
| Aparece nas coleções: | Odontologia - Campus PARQUE ECOLÓGICO | |
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