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https://repositorio.unichristus.edu.br/jspui/handle/123456789/2102| Título : | INFLUÊNCIA DA IMUNOEXPRESSÃO DAS PROTEÍNAS DO COMPLEXO MISMATCH REPAIR NO FATOR DE TRANSCRIÇÃO NUCLEAR KAPPA (NFkB) B NOS CÂNCERES DE BOCA E DE OROFARINGE |
| Autor : | Aguiar, Gladyson Lucas Rodrigues |
| metadata.dc.contributor.advisor: | Silva, Paulo Goberlânio de Barros |
| Fecha de publicación : | 2026-06-06 |
| Resumen : | Os cânceres de boca e de orofaringe representam a predominante maioria dos tumores malignos de cabeça e pescoço e tendo em vista que vias inflamatórias podem exercer importante papel no seu prognóstico, Avaliar a associação entre a imunoexpressão de proteínas do complexo Mismatch Repair nos Fatores de Transcrição NFkB nos cânceres de boca (CEC-b) e de orofaringe (CRC-o) .Foram selecionados 76 CEC-b e 52 CRC-o peças cirúrgicas cujos dados sociodemográficos como idade, sexo, grau de instrução, estado civil, profissão, raça/cor, tipo de entrada no hospital, religião, consumo de álcool e fumo foram levantados. As amostras foram submetidas a imuno-histoquímica para NF-kB p65 MSH2, MSH6, PMS2 e MLH1 em seguida contagem de células imunopositivas em núcleo e/ou citoplasma. Testes qui-quadrado, Log-Rank Mantel-Cox e regressão de Cox foram usados (p<0,05). Os tumores pT3-pT4 apresentaram perda de expressão de MLH1 (p=0,031) comparado com os tumores pT1-pT2 e os tumores com metástase nodal apresentaram perda de expressão de p53 (p=0,010) (Tabela 2) .Nos tumores de orofaringe p16+ os pacientes com idade <60 anos (82.77±21.11%) apresentaram perda de expressão de MLH1 que os pacientes com idade superior a 60 anos (82.77±21.11%, p=0,042) e os pacientes com tumores pT3-pT4 (21.89±31.74%) apresentaram menor expressão de MSH6 que os pacientes com tumores pT1-pT2 (67.09±21.30, p=0,002) (Material Suplementar 2). A perda de expressão de MMR está associada com progressão tumoral e prognóstico em tumores de cabeça e pescoço e p53, p16 e NFkB parecem ser intermediários importantes. |
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| Palabras clave : | neoplasmas de orofaringe neoplasmas de boca DNA Mismatch Repair proteínas Muts |
| URI : | https://repositorio.unichristus.edu.br/jspui/handle/123456789/2102 |
| Aparece en las colecciones: | Odontologia - Campus PARQUE ECOLÓGICO |
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